Sonodynamic therapy is a minimally invasive alternative treatment for forms of cancer that combines low-intensity ultrasound and unique chemical agents known as sonosensitizers. Sonosensitizers are compounds that can make tissue more sensitive to ultrasound. Combining low-intensity ultrasound, sonosensitizers, and molecular oxygen is believed to generate reactive oxygen species, which can contribute to cancer cell death and prevent tumor growth. The exact mechanisms are not well known, though sonodynamic therapy offers an advantage to other cancer treatment options. Along with its generally noninvasive nature, this cancer therapy also allows for deeper penetration as ultrasound can be focused tightly and easily reach the soft tissue. Sonodynamic therapy may also increase the effectiveness of chemotherapy in patients and other types of cancer treatment.